Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and
despite significant efforts that have been put into studying the pathogenesis of HIV infection …

Innate immunity is an intrinsic baseline defense in cells, with its earliest origins in bacteria,
and with key roles in defense against pathogens and in the activation of B and T cell …

Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-
effective vaccines and treatments. Here we investigate the immune events from the acute …

Chronic inflammation and immune dysfunction play a key role in the development of non-
AIDS–related comorbidities. The aim of our study was to characterize the functional …

Abstract Development of effective human immunodeficiency virus 1 (HIV-1) vaccines
requires synergy between innate and adaptive immune cells. Here we show that induction of …

Abstract Background The ALVAC/gp120+ MF59 vaccines in the HIV Vaccine Trials Network
(HVTN) 702 efficacy trial did not prevent human immunodeficiency virus-1 (HIV-1) …

The development of an effective vaccine to protect against HIV acquisition will be greatly
bolstered by in-depth understanding of the innate and adaptive responses to vaccination …

With the spotlight on cancer immunotherapy and the expanding use of immune checkpoint
inhibitors, strategies to improve the response rate and duration of current cancer …

The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous
epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver …

Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We
hypothesized that vaccines that induce both high-magnitude CD8+ T cell responses and …