2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

Abstract The 2-His-1-carboxylate facial triad is a widely used scaffold to bind the iron center
in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Carbapenems are antibiotics of last resort in the clinic. Owing to their potency and broad-
spectrum activity, they are an important part of the antibiotic arsenal. The vital role of …

Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …

Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …

Abstract A 2.4-Å-resolution X-ray crystal structure of the carrier-protein-independent
halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi …

Hyoscyamine 6β-hydroxylase (H6H) is an iron (II)-and 2-oxoglutarate-dependent (Fe/2OG)
oxygenase that produces the prolifically administered antinausea drug, scopolamine. After …