Cells are equipped with asymmetrically localised and functionally specialised components,
including cytoskeletal structures and organelles. Positioning these components to specific …

The centrosome is a main orchestrator of the animal cellular microtubule cytoskeleton.
Dissecting its structure and assembly mechanisms has been a goal of cell biologists for over …

Centrioles are microtubule-based cylindrical ultrastructures characterized by their definite
size and robustness. The molecular capping protein, CPAP (also known as CENPJ) …

Centrosome amplification (CA) is a common feature of human tumors, but it is not clear
whether this is a cause or a consequence of cancer. The centrosome amplification observed …

Mutations in genes that disrupt centrosome structure or function can cause congenital
kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how …

The centrosome regulates mammalian meiosis by affecting recombination, synapsis,
chromosome segregation, and spermiogenesis. Cep72 is one of the critical components of …

The centrosome plays a crucial role in facilitating mitotic spindle assembly through its
microtubule organizing capacities. Analyzing the composition, structure, and functions of …

Centrosome abnormalities are the hallmark of cancer. How it affects tumorigenesis is still a
mystery. However, the presence of more than two centrosomes at the onset of mitosis often …

Background Abnormalities of centrosomes, the major microtubular organizing centers of
animal cells and regulators of cell cycle progression, usually accelerate tumor progression …

Cilia are membrane-surrounded sensory cellular organelles that can also create motion to
move fluids or propel the cell to which they are attached. New work shows that, whereas …