Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have
been investigated for their therapeutic potential in various clinical disorders, including …

Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …

Aging research has experienced a burst of scientific efforts in the last decades as the
growing ratio of elderly people has begun to pose an increased burden on the healthcare …

In the current work, the adsorption of Zolinza (ZOL) drug on B 12 N 12 and Al 12 N 12
nanocages was investigated using density functional theory (DFT) and time-dependent DFT …

Central nervous system atypical teratoid/rhabdoid tumors (ATRTs) are rare and aggressive
tumors with a very poor prognosis. Current treatments for ATRT include resection of the …

Background The conversion of the epithelial phenotype of cancer cells into cells with a
mesenchymal phenotype-so-called epithelial–mesenchymal transition (EMT)-has been …

Canine urothelial carcinoma (cUC) is the most common tumor of the lower urinary tract in
dogs. Although chemotherapy and radical surgery have improved the overall survival, most …

Cancer metabolism is how cancer cells utilize nutrients and energy to support their growth
and proliferation. Unlike normal cells, cancer cells have a unique metabolic profile that …

AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for
multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and …

A plethora of data has highlighted the role of epigenetics in the development of cancer.
Initiation and progression of different cancer types are associated with a variety of changes …