Off-target effects of drugs that disrupt human mitochondrial DNA maintenance
MJ Young - Frontiers in molecular biosciences, 2017 - frontiersin.org
Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human
immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome …
immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome …
Risk of hepatocellular carcinoma in patients treated with entecavir vs tenofovir for chronic hepatitis B: a Korean nationwide cohort study
Importance Entecavir and tenofovir disoproxil fumarate have comparable efficacy in
achieving surrogate end points, including virologic response, and are equally recommended …
achieving surrogate end points, including virologic response, and are equally recommended …
[HTML][HTML] Polymerase iota-an odd sibling among Y family polymerases
J McIntyre - DNA repair, 2020 - Elsevier
It has been two decades since the discovery of the most mutagenic human DNA
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …
The antiretroviral 2′, 3′-dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures
CKJ Young, JH Wheeler, MM Rahman… - Journal of Biological …, 2021 - ASBMB
Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human
immunodeficiency virus infection, and their use can cause mitochondrial toxicity, including …
immunodeficiency virus infection, and their use can cause mitochondrial toxicity, including …
Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance
M Hung, EJ Tokarsky, L Lagpacan, L Zhang… - Communications …, 2019 - nature.com
Abstract Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with
unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors …
unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors …
Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases
BA Maxwell, Z Suo - Biochemistry, 2014 - ACS Publications
The kinetic mechanisms by which DNA polymerases catalyze DNA replication and repair
have long been areas of active research. Recently discovered Y-family DNA polymerases …
have long been areas of active research. Recently discovered Y-family DNA polymerases …
Hepatitis B virus treatment and hepatocellular carcinoma: controversies and approaches to consensus
SK Kim, T Fujii, SR Kim, A Nakai, YS Lim, S Hagiwara… - Liver Cancer, 2022 - karger.com
Background: Long-term therapy with nucleos (t) ide analogs (NAs) such as entecavir (ETV)
and tenofovir disoproxil fumarate (TDF) favorably affects the incidence of hepatocellular …
and tenofovir disoproxil fumarate (TDF) favorably affects the incidence of hepatocellular …
Interlocking activities of DNA polymerase β in the base excision repair pathway
Base excision repair (BER) is a major cellular pathway for DNA damage repair. During BER,
DNA polymerase β (Polβ) is hypothesized to first perform gap-filling DNA synthesis by its …
DNA polymerase β (Polβ) is hypothesized to first perform gap-filling DNA synthesis by its …
Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol
EJ Tokarsky, PC Wallenmeyer, KK Phi, Z Suo - DNA repair, 2017 - Elsevier
Human PrimPol is a recently discovered bifunctional enzyme that displays DNA template-
directed primase and polymerase activities. PrimPol has been implicated in nuclear and …
directed primase and polymerase activities. PrimPol has been implicated in nuclear and …
Genetic evidence for genotoxic effect of entecavir, an anti-hepatitis B virus nucleotide analog
L Jiang, X Wu, F He, Y Liu, X Hu, S Takeda, Y Qing - PLoS One, 2016 - journals.plos.org
Nucleoside analogues (NAs) have been the most frequently used treatment option for
chronic hepatitis B patients. However, they may have genotoxic potentials due to their …
chronic hepatitis B patients. However, they may have genotoxic potentials due to their …