H2S in Critical Illness—A New Horizon for Sodium Thiosulfate?

T Merz, O McCook, C Brucker, C Waller, E Calzia… - Biomolecules, 2022 - mdpi.com
Ever since the discovery of endogenous H2S and the identification of its cytoprotective
properties, efforts have been made to develop strategies to use H2S as a therapeutic agent …

Early life stress, brain development, and obesity risk: is oxytocin the missing link?

G Colleluori, C Galli, I Severi, J Perugini, A Giordano - Cells, 2022 - mdpi.com
Obesity disease results from a dysfunctional modulation of the energy balance whose
master regulator is the central nervous system. The neural circuitries involved in such …

[HTML][HTML] Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation

N Duque-Wilckens, R Teis, E Sarno, F Stoelting… - Brain, behavior, and …, 2022 - Elsevier
Exposure to early life adversity (ELA) in the form of physical and/or psychological abuse or
neglect increases the risk of developing psychiatric and inflammatory disorders later in life. It …

The role of glucocorticoid receptor and oxytocin receptor in the septic heart in a clinically relevant, resuscitated porcine model with underlying atherosclerosis

T Merz, N Denoix, D Wigger, C Waller… - Frontiers in …, 2020 - frontiersin.org
The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and
comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated …

Childhood separation from parents with cognitive and psychopathological outcomes in adolescence

X Zhao, A Zhang, W Liu, F Tao… - Developmental Science, 2023 - Wiley Online Library
To examine the effects of childhood parent‐child separation with varying duration and form
on later cognitive performance and psychopathological problems over a 6‐year period, we …

Aberrant early in life stimulation of the stress-response system affects emotional contagion and oxytocin regulation in adult male mice

G Laviola, LM Busdraghi, N Meschino… - International Journal of …, 2021 - mdpi.com
Results over the last decades have provided evidence suggesting that HPA axis dysfunction
is a major risk factor predisposing to the development of psychopathological behaviour. This …

Cerebral Immunohistochemical Characterization of the H2S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma

N Denoix, T Merz, S Unmuth, A Hoffmann… - Frontiers in …, 2020 - frontiersin.org
The hydrogen sulfide (H2S) and the oxytocin/oxytocin receptor (OT/OTR) systems interact in
trauma and are implicated in vascular protection and regulation of fluid homeostasis. Acute …

H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease

O McCook, N Denoix, P Radermacher… - Journal of Clinical …, 2021 - mdpi.com
Today it is well established that early life stress leads to cardiovascular programming that
manifests in cardiovascular disease, but the mechanisms by which this occurs, are not fully …

The interaction of the endogenous hydrogen sulfide and oxytocin systems in fluid regulation and the cardiovascular system

N Denoix, O McCook, S Ecker, R Wang, C Waller… - Antioxidants, 2020 - mdpi.com
The purpose of this review is to explore the parallel roles and interaction of hydrogen sulfide
(H2S) and oxytocin (OT) in cardiovascular regulation and fluid homeostasis. Their …

Brain histology and immunohistochemistry after resuscitation from hemorrhagic shock in swine with pre-existing atherosclerosis and sodium thiosulfate (Na2S2O3) …

N Denoix, O McCook, A Scheuerle, T Kapapa… - Frontiers in …, 2022 - frontiersin.org
Background The hydrogen sulfide (H2S) and the oxytocin/oxytocin receptor (OT/OTR)
systems interact in the central nervous and cardiovascular system. As a consequence of …