Preventing polyspermy in mammalian eggs—Contributions of the membrane block and other mechanisms

JP Evans - Molecular reproduction and development, 2020 - Wiley Online Library
The egg's blocks to polyspermy (fertilization of an egg by more than one sperm) were
originally identified in marine and aquatic species with external fertilization, but polyspermy …

Knockin'on egg's door: Maternal control of egg activation that influences cortical granule exocytosis in animal species

J Rojas, F Hinostroza, S Vergara… - Frontiers in Cell and …, 2021 - frontiersin.org
Fertilization by multiple sperm leads to lethal chromosomal number abnormalities, failed
embryo development, and miscarriage. In some vertebrate and invertebrate eggs, the so …

Echinobase: a resource to support the echinoderm research community

CA Telmer, K Karimi, MM Chess, S Agalakov… - Genetics, 2024 - academic.oup.com
Abstract Echinobase (www. echinobase. org) is a model organism knowledgebase serving
as a resource for the community that studies echinoderms, a phylum of marine invertebrates …

Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels

MB Hawn, E Akin, HC Hartzell, IA Greenwood… - Channels, 2021 - Taylor & Francis
ABSTRACT Ca2+-activated Cl− channels (CaCCs) perform a multitude of functions
including the control of cell excitability, regulation of cell volume and ionic homeostasis …

Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure

Y Peng, Y Lin, K Deng, J Shen, Y Cui, J Liu… - Journal of Assisted …, 2023 - Springer
Purpose To investigate the genetic causes of polyspermy and total fertilization failure (TFF)
in two independent male patients suffering from male infertility. Methods …

MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans

I Kawasaki, K Sugiura, T Sasaki, N Matsuda… - Nature …, 2024 - nature.com
In many sexually reproducing organisms, oocytes are fundamentally fertilized with one
sperm. In Caenorhabditis elegans, chitin layer formation after fertilization by the EGG …

Cellular and molecular aspects of oocyte maturation and fertilization: A perspective from the actin cytoskeleton

L Santella, N Limatola, JT Chun - Zoological Letters, 2020 - Springer
Much of the scientific knowledge on oocyte maturation, fertilization, and embryonic
development has come from the experiments using gametes of marine organisms that …

TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs

KM Komondor, RE Bainbridge, KG Sharp… - Journal of General …, 2023 - rupress.org
Fertilization of an egg by more than one sperm, a condition known as polyspermy, leads to
gross chromosomal abnormalities and is embryonic lethal for most animals. Consequently …

[HTML][HTML] Sulfate toxicity to early life stages of European whitefish (Coregonus lavaretus) in soft freshwater

J Karjalainen, M Mäkinen, AK Karjalainen - … and Environmental Safety, 2021 - Elsevier
Highlights•Toxicity of sulfate to fish during early development in soft freshwater tested.•Egg
fertilization were the most sensitive stage of whitefish to sulfate.•After early development, the …

Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes

N Gupta, C Soriano-Úbeda, P Stein, V Savy, BN Papas… - Cell reports, 2023 - cell.com
TRPM7 (transient receptor potential cation channel subfamily M member 7) is a chanzyme
with channel and kinase domains essential for embryo development. Using gamete-specific …