Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …

Purpose of review: Diabetic nephropathy (DN) is a progressive kidney disease caused by
alterations in kidney architecture and function, and constitutes one of the leading causes of …

Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …

背景既往研究发现二甲双胍具有糖尿病肾脏保护作用. 此研究中, 通过测定不同剂量二甲双胍对2
型糖尿病大鼠模型肾组织nephrin 表达的影响, 以此探讨其对肾脏足细胞保护作用的潜在机制 …

Diabetic nephropathy (DN) is a serious complication of diabetes associated with increased
risk of mortality, and cardiovascular and renal outcomes. Diagnostic markers to detect DN at …

Diabetic kidney disease (DKD) is an important public health problem. Podocyte injury is a
central event in the mechanism of DKD development. Podocytes are terminally …

Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first
identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1) …

Diabetic nephropathy (DN) is a well-described complication of diabetes mellitus and the
leading cause of end stage renal disease (ESRD). Although increased albuminuria has …

Abstract Humanin (HN) is a 24-amino acid mitochondrial-derived polypeptide with cyto-
protective and anti-apoptotic effects that regulates the mitochondrial functions under stress …