The immunogenetics of multiple sclerosis: A comprehensive review

JA Hollenbach, JR Oksenberg - Journal of autoimmunity, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Towards a global view of multiple sclerosis genetics

BM Jacobs, M Peter, G Giovannoni, AJ Noyce… - Nature Reviews …, 2022 - nature.com
Multiple sclerosis (MS) is a neuroimmunological disorder of the CNS with a strong heritable
component. The genetic architecture of MS susceptibility is well understood in populations of …

HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis

D Guimaraães Brum, AA Barreira… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple
sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is …

Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean …

R Deschamps, L Paturel, S Jeannin… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: Despite similarities, neuromyelitis optica (NMO) can be distinguished from
multiple sclerosis (MS) by clinical, radiological and serological findings. Objective: This case …

Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry

BRA Ramos, MPB D'Elia, MAT Amador, NPC Santos… - Genetica, 2016 - Springer
Ancestry information can be useful in investigations of diseases with a genetic or infectious
background. As the Brazilian population is highly admixed physical traits tend to be poor …

Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population

AH Beecham, L Amezcua, A Chinea, CP Manrique… - PloS one, 2022 - journals.plos.org
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to
multiple sclerosis (MS) susceptibility, with 32 independent effects across the region …

Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of …

BRA Ramos, ND Mendes, AA Tanikawa… - BMC Pregnancy and …, 2016 - Springer
Background A genetic predisposition to Preterm Labor (PTL) and Preterm Premature
Rupture of Membranes (PPROM) has been suggested; however the relevance of …

Relationship between HLA-DRB1 polymorphism and susceptibility or resistance to multiple sclerosis in Caucasians: a meta-analysis of non-family-based studies

Q Zhang, CY Lin, Q Dong, J Wang, W Wang - Autoimmunity reviews, 2011 - Elsevier
Objective To identify the contribution of HLA-DRB1 alleles to susceptibility or resistance to
multiple sclerosis (MS) in Caucasians through a meta-analysis of non-family-based studies …

The prevalence of multiple sclerosis in Belo Horizonte, Brazil

MA Lana-Peixoto, ERC Frota, GB Campos… - Arquivos de Neuro …, 2012 - SciELO Brasil
Investigations on the prevalence rates of multiple sclerosis (MS) around the world have
yielded important clues on the interplay between genetic susceptibility and environmental …

Prevalence of multiple sclerosis in Latin America and its relationship with European migration

E Correa, V Paredes… - Multiple Sclerosis Journal …, 2016 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic, degenerative autoimmune inflammatory disease of the
central nervous system. The prevalence is different in every continent, changing according …