Ultrasound can penetrate deep into tissues and interact with human tissue via thermal and
mechanical mechanisms. The ability to focus an ultrasound beam and its energy onto …

Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for
intracranial ablation in 1942, many strides have been made toward the treatment of several …

OBJECTIVE Histotripsy is an ultrasound-based treatment modality relying on the generation
of targeted cavitation bubble clouds, which mechanically fractionate tissue. The purpose of …

Histotripsy has been previously shown to treat a wide range of locations through excised
human skulls in vitro. In this article, a transcranial magnetic resonance (MR)-guided …

Oncology and cerebrovascular disease constitute two of the most common diseases
afflicting the central nervous system. Standard of treatment of these pathologies is based on …

Cavitation events generated during histotripsy therapy generate large acoustic cavitation
emission (ACE) signals that can be detected through the skull. This article investigates the …

Histotripsy has been previously applied to target various cranial locations in vitro through an
excised human skull. Recently, a transcranial magnetic resonance (MR)-guided histotripsy …

Purpose: Ultrasound can be used to noninvasively produce different bioeffects via viscous
heating, acoustic cavitation, or their combination, and these effects can be exploited to …

Focused ultrasound (FUS) has been under investigation for neurosurgical applications since
the 1940s. Early experiments demonstrated ultrasound as an effective tool for the creation of …

The ability to focus acoustic energy through the intact skull on to targets millimeters in size
represents an important milestone in the development of neurotherapeutics. Magnetic …