“Epigenetic clocks”: Theory and applications in human biology

CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …

Does reproduction shorten telomeres? Towards integrating individual quality with life‐history strategies in telomere biology

J Sudyka - BioEssays, 2019 - Wiley Online Library
Reproduction, a basic property of biological life, entails costs for an organism, ultimately
detectable as reduction in survival prospects. Telomeres are an excellent candidate …

Biological age is increased by stress and restored upon recovery

JR Poganik, B Zhang, GS Baht, A Tyshkovskiy, A Deik… - Cell Metabolism, 2023 - cell.com
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Pregnancy is linked to faster epigenetic aging in young women

CP Ryan, NR Lee, DB Carba… - Proceedings of the …, 2024 - National Acad Sciences
A central prediction of evolutionary theory is that energy invested into reproduction comes at
the expense of somatic maintenance and repair, accelerating biological aging. Supporting …

Psychosocial stress and epigenetic aging

H Palma-Gudiel, L Fañanás, S Horvath… - International review of …, 2020 - Elsevier
Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

Costs of reproduction and ageing in the human female

G Jasienska - … Transactions of the Royal Society B, 2020 - royalsocietypublishing.org
Evolutionary theories of ageing point to reproduction as a significant factor to consider when
asking why ageing occurs and why there is inter-individual variation in its progression …

Balancing growth, reproduction, maintenance, and activity in evolved energy economies

H Pontzer, A McGrosky - Current Biology, 2022 - cell.com
Economic models predominate in life history research, which investigates the allocation of
an organism's resources to growth, reproduction, and maintenance. These approaches …

Longer telomeres during early life predict higher lifetime reproductive success in females but not males

BJ Heidinger, AC Kucera… - Proceedings of the …, 2021 - royalsocietypublishing.org
The mechanisms that contribute to variation in lifetime reproductive success are not well
understood. One possibility is that telomeres, conserved DNA sequences at chromosome …

Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation

EB Quinn, CJ Hsiao, FM Maisha, CJ Mulligan - Epigenetics, 2023 - Taylor & Francis
Prenatal maternal stress has a negative impact on child health but the mechanisms through
which maternal stress affects child health are unclear. Epigenetic variation, such as DNA …

Telomere length is repeatable, shortens with age and reproductive success, and predicts remaining lifespan in a long‐lived seabird

C Bichet, S Bouwhuis, C Bauch, S Verhulst… - Molecular …, 2020 - Wiley Online Library
Telomeres are protective caps at the end of chromosomes, and their length is positively
correlated with individual health and lifespan across taxa. Longitudinal studies have …