Strictly lytic phages have been consensually preferred for phage therapy purposes. In
contrast, temperate phages have been avoided due to an inherent capacity to mediate …

Highlights•Synthetic biology enables efficient phage genome engineering.•Phages with
tunable host range and antimicrobial payload delivery enhance efficacy.•Phage design …

Actinobacteriophages are viruses that infect bacterial hosts in the phylum Actinobacteria.
More than 17,000 actinobacteriophages have been described and over 3,000 complete …

Mycobacteriophages—bacteriophages infecting Mycobacterium hosts—contribute
substantially to our understanding of viral diversity and evolution, provide resources for …

The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

The success of phage therapy is dependent on the development of strategies able to
overcome the limitations of bacteriophages as therapeutic agents, the creation of an …

Soon after their discovery in the early 20th century, bacteriophages were recognized to have
great potential as antimicrobial agents, a potential that has yet to be fully realized. The …

Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth,
constituting a virtually unlimited resource to explore the development of biomedical …

Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

Since their independent discovery by Frederick Twort in 1915 and Felix d'Herelle in 1917,
bacteriophages have captured the attention of scientists for more than a century. They are …