Recombinant proteins are gaining enormous importance these days due to their wide
application as biopharmaceutical products and proven safety record. Various recombinant …

Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a
structural protein of flavivirus, is dimeric and alpha-helical, with several special structural …

Dengue viruses are emerging mosquito-borne pathogens belonging to Flaviviridae family
which are transmitted to humans via the bites of infected mosquitoes Aedes aegypti and …

Dengue results in substantial human morbidity and significant socio-economic impacts, but
a specific dengue therapeutic is not available. The currently available dengue vaccine has …

This article aims to review the present status of anti-flavivirus subunit vaccines, both those at
the experimental stage and those already available for clinical use. Aspects regarding …

Despite the rapid development of vaccines against COVID-19, they have important
limitations, such as safety issues, the scope of their efficacy, and the induction of mucosal …

Dengue represents a significant and growing public health problem across the globe, with
approximately half of the world's population at risk. The increasing and expanding burden of …

Despite the considerable effort that has been invested in elucidating the mechanisms of
protection and immunopathogenesis associated with dengue virus infections, a reliable …

We describe the preclinical development of a dengue virus vaccine targeting the dengue
virus serotype 2 (DENV2) envelope domain III (EDIII). This study provides proof-of-principle …

Dengue is an infectious disease caused by dengue virus (DENV) and is a serious global
burden. Antibody-dependent enhancement and the ability of DENV to infect immune cells …