Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Background. Antiretroviral therapy has reduced the incidence of adverse events and early
mortality in HIV-infected persons. Despite these benefits, important comorbidities that …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

Chronic antigenic stimulation leads to gradual accumulation of late‐differentiated, antigen‐
specific, oligoclonal T cells, particularly within the CD8+ T‐cell compartment. They are …

The impact of intrinsic aging upon human peripheral blood T cell subsets remains
incompletely quantified and understood. This impact must be distinguished from the …

Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people
worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious …

Background Studies have suggested that CMV infection may influence cardiovascular
disease (CVD) risk and mortality. However, there have been no large-scale examinations of …

The deterioration in immune function with aging is thought to make a major contribution to
the increased morbidity and mortality from infectious disease in old age. One aspect of …

Until the mid-20th century, infectious diseases were the major cause of morbidity and
mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced …