Applied machine learning as a driver for polymeric biomaterials design

SM McDonald, EK Augustine, Q Lanners… - Nature …, 2023 - nature.com
Polymers are ubiquitous to almost every aspect of modern society and their use in medical
products is similarly pervasive. Despite this, the diversity in commercial polymers used in …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Biomaterialomics: Data science-driven pathways to develop fourth-generation biomaterials

B Basu, NH Gowtham, Y Xiao, SR Kalidindi, KW Leong - Acta Biomaterialia, 2022 - Elsevier
Conventional approaches to developing biomaterials and implants require intuitive tailoring
of manufacturing protocols and biocompatibility assessment. This leads to longer …

Materials genome in action: identifying the performance limits of physical hydrogen storage

AW Thornton, CM Simon, J Kim, O Kwon… - Chemistry of …, 2017 - ACS Publications
The Materials Genome is in action: the molecular codes for millions of materials have been
sequenced, predictive models have been developed, and now the challenge of hydrogen …

A biomimetic non‐antibiotic approach to eradicate drug‐resistant infections

Y Zhao, Q Guo, X Dai, X Wei, Y Yu, X Chen… - Advanced …, 2019 - Wiley Online Library
The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to
be properly addressed. In particular, for drug‐resistant strains, limited medication is …

Recent advances in engineering topography mediated antibacterial surfaces

J Hasan, K Chatterjee - Nanoscale, 2015 - pubs.rsc.org
The tendency of bacterial cells to adhere and colonize a material surface leading to biofilm
formation is a fundamental challenge underlying many different applications including …

Understanding the roles of the “two QSARs”

T Fujita, DA Winkler - Journal of chemical information and …, 2016 - ACS Publications
Quantitative structure–activity relationship (QSAR) modeling has matured over the past 50
years and has been very useful in discovering and optimizing drug leads. Although its roots …

Biomaterial strategies to combat implant infections: new perspectives to old challenges

A Braem, NHN Kamarudin, N Bhaskar… - International …, 2023 - journals.sagepub.com
Peri-implant infection is rapidly becoming an–if not the most–important clinical challenge for
indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of …

Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa

BH Neufeld, MJ Neufeld, A Lutzke… - Advanced Functional …, 2017 - Wiley Online Library
An 85% reduction in the bacterial attachment of Pseudomonas aeruginosa is achieved
using a water‐stable metal–organic framework (MOF) blended with chitosan. These …

Mapping biomaterial complexity by machine learning

E Ahmed, P Mulay, C Ramirez… - … Engineering Part A, 2024 - liebertpub.com
Biomaterials often have subtle properties that ultimately drive their bespoke performance.
Given this nuanced structure–function behavior, the standard scientific approach of one …