Advances in Fasciola hepatica research using 'omics' technologies

K Cwiklinski, JP Dalton - International journal for parasitology, 2018 - Elsevier
The liver fluke Fasciola hepatica is an economically important pathogen of livestock
worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on …

Proteomic insights into the biology of the most important foodborne parasites in Europe

R Stryiński, E Łopieńska-Biernat, M Carrera - Foods, 2020 - mdpi.com
Foodborne parasitoses compared with bacterial and viral-caused diseases seem to be
neglected, and their unrecognition is a serious issue. Parasitic diseases transmitted by food …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for …

CN Davis, H Phillips, JJ Tomes, MT Swain… - PLoS neglected …, 2019 - journals.plos.org
Background Robust protocols for the isolation of extracellular vesicles (EVs) from the rest of
their excretory-secretory products are necessary for downstream studies and application …

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the …

K Cwiklinski, MW Robinson, S Donnelly, JP Dalton - BMC genomics, 2021 - Springer
Background The major pathogenesis associated with Fasciola hepatica infection results
from the extensive tissue damage caused by the tunnelling and feeding activity of immature …

Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands

MJ Ramos-Benítez, C Ruiz-Jiménez, V Aguayo… - Scientific reports, 2017 - nature.com
Recently, we reported that a native Fasciola hepatica fatty acid binding protein (FABP)
termed Fh12 is a powerful anti-inflammatory protein capable of suppressing the LPS …

Eudiplozoon nipponicum (Monogenea, Diplozoidae) and its adaptation to haematophagy as revealed by transcriptome and secretome profiling

J Vorel, K Cwiklinski, P Roudnický, J Ilgová… - BMC genomics, 2021 - Springer
Background Ectoparasites from the family Diplozoidae (Platyhelminthes, Monogenea)
belong to obligate haematophagous helminths of cyprinid fish. Current knowledge of these …

Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets

JA Bélgamo, LN Alberca, JL Pórfido… - Journal of Computer …, 2020 - Springer
Fatty acid binding proteins (FABPs) are small intracellular proteins that reversibly bind fatty
acids and other hydrophobic ligands. In cestodes, due to their inability to synthesise fatty …

[HTML][HTML] Molecular interactions in an holobiont-pathogen model: Integromics in gilthead seabream infected with Sparicotyle chrysophrii

S Toxqui-Rodríguez, E Riera-Ferrer, R Del Pozo… - Aquaculture, 2024 - Elsevier
The gill ectoparasite Sparicotyle chrysophrii is the major parasitic pathogen in gilthead
seabream (Sparus aurata) aquaculture with limited management and treatment strategies. In …

Function of lipid binding proteins of parasitic helminths: still a long road

JF Lombardo, JL Pórfido, MS Sisti, AN Giorello… - Parasitology …, 2022 - Springer
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …