Mitochondria harbor their own genetic system, yet critically depend on the import of a
number of nuclear-encoded macromolecules to ensure their expression. In all eukaryotes …

Ribonucleic acid (RNA) molecules can be easily attacked by reactive oxygen species
(ROS), which are produced during normal cellular metabolism and under various oxidative …

Objective Metabolic-associated fatty liver disease (MAFLD) represents one of the most
prevalent chronic liver conditions worldwide, but its precise pathogenesis remains unclear …

Mitochondrial gene editing holds great promise as a therapeutic approach for mitochondrial
diseases caused by mutations in the mitochondrial DNA (mtDNA). Current strategies focus …

Abstract Background Aicardi-Goutières syndrome (AGS) is a clinically and genetically
heterogenous autoinflammatory disorder caused by constitutive activation of the type I …

Objective Dominant spinocerebellar ataxias (SCA) are characterized by genetic
heterogeneity. Some mapped and named loci remain without a causal gene identified. Here …

Mitochondria are the power houses of eukaryote cells. These endosymbiotic organelles of
prokaryote origin are considered as semi-autonomous since they have retained a genome …

Polynucleotide phosphorylase (PNPase) is a phosphorolytic RNA exonuclease highly
conserved throughout evolution. Human PNPase (hPNPase) is located in mitochondria and …

PNPT1 (PNPase—polynucleotide phosphorylase) is involved in multiple RNA processing
functions in the mitochondria. Bi-allelic pathogenic PNPT1 variants cause heterogeneous …

Extranuclear localization of long non-coding RNAs (lncRNAs) is poorly understood. Based
on machine learning evaluations, we propose a lncRNA-mitochondrial interaction pathway …