Adipose tissue is now recognized as an important endocrine organ, capable of secreting a large number of endocrine factors which regulate a wide variety of physiological functions …
Chronic inflammation in adipose tissue plays a key role in obesity-induced insulin resistance. However, the mechanisms underlying obesity-induced inflammation remain …
X Li, J Pan, H Li, G Li, X Liu, B Liu, Z He, Z Peng… - Nature …, 2020 - nature.com
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN) …
GV Denis, MS Obin - Molecular aspects of medicine, 2013 - Elsevier
When humans eat more and exercise less, they tend to become obese and unhealthy. The molecular pathways that link obesity to serious diseases like Type 2 diabetes and …
ILMH Aye, FJ Rosario, TL Powell… - Proceedings of the …, 2015 - National Acad Sciences
Mothers with obesity or gestational diabetes mellitus have low circulating levels of adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …
T Bao, J Liu, J Leng, L Cai - Cell & Bioscience, 2021 - Springer
In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …
J Bai, C Cervantes, S He, J He, GR Plasko… - Communications …, 2020 - nature.com
Obesity is a global epidemic that is caused by excessive energy intake or inefficient energy expenditure. Brown or beige fat dissipates energy as heat through non-shivering …
M Liu, F Liu - Best practice & research Clinical endocrinology & …, 2014 - Elsevier
Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and …
M Ebrahimi-Mamaeghani, S Mohammadi… - Vascular health and …, 2015 - Taylor & Francis
The increasing prevalence of diabetes and its complications heralds an alarming situation worldwide. Obesity-associated changes in circulating adiponectin concentrations have the …