Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in
individuals previously treated with chemotherapy and/or radiation therapy. With the …

Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …

In 2022, two new classifications of myeloid neoplasms and acute leukemias were published:
the 5th edition WHO Classification (WHO-HAEM5) and the International Consensus …

Purpose: Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN).
Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk …

With advances in sequencing, individuals with clonal hematopoiesis of indeterminate
potential (CHIP) are increasingly being identified, making it essential to understand its …

Background Somatic mutations are frequently reported in individuals with cytopenia but
without a confirmed haematological diagnosis (clonal cytopenia of undetermined …

Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic
malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA …

Clonal hematopoiesis (CH) identified by somatic gene variants with variant allele fraction
(VAF)≥ 2% is associated with an increased risk of hematologic malignancy. However, CH …

Clonal hematopoiesis (CH) in autologous transplant recipients and allogeneic transplant
donors has genetic features and clinical associations that are distinct from each other and …