Importance Cognitive impairment and dementia, including Alzheimer disease (AD), are
common within the aging population, yet the factors that render the aging brain vulnerable to …

Microglia are the resident immune cells of the brain and react quickly to changes in their
environment with transcriptional regulation and morphological changes. Brain tissue injury …

The estimation of the number or density of neurons and types of glial cells and their relative
proportions in different brain areas are at the core of rigorous quantitative neuroanatomical …

Glial cells, both astrocytes and microglia, respond to neurodegenerative processes and to
brain damage by a process called reactive gliosis. This response is highly context …

The recent definition of a network of lymphatic vessels in the meninges surrounding the
brain and the spinal cord has advanced our knowledge on the functional anatomy of fluid …

Characterized by a dismal survival rate and limited response to therapy, glioblastoma (GBM)
remains one of the most aggressive human malignancies. Recent studies of the role of …

Subarachnoid hemorrhage (SAH) is an acute and severe disease with high disability and
mortality. Inflammatory reactions have been proven to occur throughout SAH. Extracellular …

Activation of metabotropic glutamate receptor 5 (mGluR5) provided neuroprotection in
multiple central nervous system injury, but the roles of mGluR5 in subarachnoid hemorrhage …

Here, we aimed to study the role and underlying mechanism of mTOR in early brain injury
(EBI) after subarachnoid hemorrhage (SAH). Experiment 1, the time course of mTOR …

Background There is growing evidence supporting the role of inflammation in aneurysmal
subarachnoid hemorrhage (aSAH) pathophysiology and it is of great interest to elucidate …