The actin filament is astonishingly well conserved across a diverse set of eukaryotic species.
It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

ADF/cofilins are key regulators of actin dynamics during cellular motility, yet their precise
role and mechanism of action are shrouded in ambiguity. Direct observation of actin …

▪ Abstract Ubiquitous among eukaryotes, the ADF/cofilins are essential proteins responsible
for the high turnover rates of actin filaments in vivo. In vertebrates, ADF and cofilin are …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-
specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

Summary Actin-depolymerizing factor (ADF)/cofilins contribute to cytoskeletal dynamics by
promoting rapid actin filament disassembly. In the classical view, ADF/cofilin sever filaments …