HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation
and cell death, HMGB1 can function as an alarm protein (alarmin) or damage-associated …

Dendritic cells (DCs) initiate and control immune responses, participate in the maintenance
of immunological tolerance and are pivotal players in the pathogenesis of autoimmunity. In …

The intracellular protein HMGB1 is released from cells and acts as a damage-associated
molecular pattern molecule during many diseases, including inflammatory bowel disease …

Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of
insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with …

Diabetes is a systemic disease that can cause brain damage such as synaptic impairments
in the hippocampus, which is partly because of neuroinflammation induced by …

BACKGROUND AND PURPOSE Recently, metformin, a well‐known anti‐diabetic drug, has
been shown to possess anti‐inflammatory activities. This study investigated the effect of …

Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin
deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age …

Renal fibrosis, particularly tubulointerstitial fibrosis is considered to be the final manifestation
of almost all chronic kidney diseases (CKDs). Herein we demonstrated evidence that CHOP …

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that
has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair …

OBJECTIVES: High-mobility group box 1 (HMGB1) is a nuclear protein with functions in the
regulation of transcription. In inflammatory conditions, HMGB1 is actively secreted from …