Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different
epitopes or antigens. Although a series of challenges, especially immunogenicity and chain …

Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are
aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic …

Abstract Purpose: The CANON [CA VATAK in NON–muscle-invasive bladder cancer
(NMIBC)] study evaluated a novel ICAM-1–targeted immunotherapeutic-coxsackievirus A21 …

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing
progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group …

Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the
treatment of cancer. However, attenuation of virulence, which is generally required for the …

Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an
ability to elicit curative effects via systemic administration. Tumor cells often create an …

With the increased worldwide burden of cancer, including aggressive and resistant cancers,
oncolytic virotherapy has emerged as a viable therapeutic option. Oncolytic herpes simplex …

Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in
the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent …

Simple Summary Diffuse intrinsic pontine glioma (DIPG) is a malignant primary glial tumor
that occurs in all age groups but predominates in children and is estimated to account for …