Arterial thrombosis—insidious, unpredictable and deadly

SP Jackson - Nature medicine, 2011 - nature.com
The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Antiplatelet therapy: in search of the'magic bullet'

SP Jackson, SM Schoenwaelder - Nature Reviews Drug Discovery, 2003 - nature.com
The central importance of platelets in the development of arterial thrombosis and
cardiovascular disease is well established. No other single cell type is responsible for as …

Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models

A Razavi, E Shirani, MR Sadeghi - Journal of biomechanics, 2011 - Elsevier
Symmetrical 30–60% stenosis in a common carotid artery under unsteady flow condition for
Newtonian and six non-Newtonian viscosity models are investigated numerically. Results …

An unsteady analysis of non-Newtonian blood flow through tapered arteries with a stenosis

PK Mandal - International journal of non-linear mechanics, 2005 - Elsevier
The problem of non-Newtonian and nonlinear blood flow through a stenosed artery is solved
numerically where the non-Newtonian rheology of the flowing blood is characterised by the …

3D MRI-based multicomponent FSI models for atherosclerotic plaques

D Tang, C Yang, J Zheng, PK Woodard… - Annals of biomedical …, 2004 - Springer
Abstract A three-dimensional (3D) MRI-based computational model with multicomponent
plaque structure and fluid–structure interactions (FSI) is introduced to perform mechanical …

Three-dimensional instabilities and transition of steady and pulsatile axisymmetric stenotic flows

SJ Sherwin, HM Blackburn - Journal of Fluid Mechanics, 2005 - cambridge.org
A straight tube with a smooth axisymmetric constriction is an idealized representation of a
stenosed artery. We examine the three-dimensional instabilities and transition to turbulence …

Direct numerical simulation of transitional flow in a stenosed carotid bifurcation

SE Lee, SW Lee, PF Fischer, HS Bassiouny… - Journal of …, 2008 - Elsevier
The blood flow dynamics of a stenosed, subject-specific, carotid bifurcation were numerically
simulated using the spectral element method. Pulsatile inlet conditions were based on in …

A review of arterial phantom fabrication methods for flow measurement using PIV techniques

SG Yazdi, PH Geoghegan, PD Docherty… - Annals of Biomedical …, 2018 - Springer
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
western world. In the last three decades, fluid dynamics investigations have been an …

Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses

MX Li, JJ Beech-Brandt, LR John, PR Hoskins… - Journal of …, 2007 - Elsevier
Hemodynamics factors and biomechanical forces play key roles in atherogenesis, plaque
development and final rupture. In this paper, we investigated the flow field and stress field for …

[HTML][HTML] Numerical analysis of the effect of turbulence transition on the hemodynamic parameters in human coronary arteries

A Mahalingam, UU Gawandalkar, G Kini… - Cardiovascular …, 2016 - ncbi.nlm.nih.gov
Background Local hemodynamics plays an important role in atherogenesis and the
progression of coronary atherosclerosis disease (CAD). The primary biological effect due to …