The emerging importance of lymphatics in health and disease: an NIH workshop report

BJ Mehrara, AJ Radtke, GJ Randolph… - The Journal of …, 2023 - Am Soc Clin Investig
The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

The vicious circle of stasis, inflammation, and fibrosis in lymphedema

S Brown, JH Dayan, RP Kataru… - Plastic and …, 2023 - journals.lww.com
Lymphedema is a progressive disease of the lymphatic system arising from impaired
lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary …

Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway

M Xiang, T Liu, C Tian, K Ma, J Gou, R Huang… - Pharmacological …, 2022 - Elsevier
Kinsenoside (KD) exhibits anti-inflammatory and immunosuppressive effects. Dendritic cells
(DCs) are critical regulators of the pathologic inflammatory milieu in liver fibrosis (LF) …

Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor

RS Czepielewski, EC Erlich, EJ Onufer, S Young… - Immunity, 2021 - cell.com
Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are
features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact …

[HTML][HTML] VEGFR3 is required for button junction formation in lymphatic vessels

M Jannaway, D Iyer, DM Mastrogiacomo, K Li… - Cell reports, 2023 - cell.com
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of
large macromolecules, chylomicrons, and fluid from the interstitium. While excessive …

The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development

J Du, P Liu, Y Zhou, S Misener… - The Journal of …, 2024 - Am Soc Clin Investig
Lymphedema is a debilitating disease with no effective cure and affects an estimated 250
million individuals worldwide. Prior studies have identified mutations in piezo-type …

Single-cell expression atlas reveals cell heterogeneity in the creeping fat of Crohn's disease

W Shu, Y Wang, C Li, L Zhang… - Inflammatory Bowel …, 2023 - academic.oup.com
Abstract Background Creeping fat (CrF) has been recognized to play a positive role in
Crohn's disease (CD) progression, yet the cellular compositions within mesenteric adipose …

[HTML][HTML] Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

F Ruperti, I Becher, A Stokkermans, L Wang… - Current Biology, 2024 - cell.com
A hallmark of animals is the coordination of whole-body movement. Neurons and muscles
are central to this, yet coordinated movements also exist in sponges that lack these cell …

Current status of lymphangiogenesis: molecular mechanism, immune tolerance, and application prospect

H Deng, J Zhang, F Wu, F Wei, W Han, X Xu, Y Zhang - Cancers, 2023 - mdpi.com
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures
essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport …

Lymphatic collecting vessel: New perspectives on mechanisms of contractile regulation and potential lymphatic contractile pathways to target in obesity and metabolic …

Y Lee, SD Zawieja, M Muthuchamy - Frontiers in Pharmacology, 2022 - frontiersin.org
Obesity and metabolic syndrome pose a significant risk for developing cardiovascular
disease and remain a critical healthcare challenge. Given the lymphatic system's role as a …