Host-microbe interactions at the blood-brain barrier through the lens of induced pluripotent stem cell-derived brain-like endothelial cells

N Vollmuth, J Sin, BJ Kim - Mbio, 2024 - Am Soc Microbiol
Microbe-induced meningoencephalitis/meningitis is a life-threatening infection of the central
nervous system (CNS) that occurs when pathogens are able to cross the blood-brain barrier …

Coxsackievirus B3 infects and disrupts human induced-pluripotent stem cell derived brain-like endothelial cells

J Mamana, GM Humber, ER Espinal, S Seo… - Frontiers in Cellular …, 2023 - frontiersin.org
Coxsackievirus B3 (CVB3) is a significant human pathogen that is commonly found
worldwide. CVB3 among other enteroviruses, are the leading causes of aseptic meningo …

Group B Streptococcus-Induced Macropinocytosis Contributes to Bacterial Invasion of Brain Endothelial Cells

ER Espinal, T Matthews, BM Holder, OB Bee… - Pathogens, 2022 - mdpi.com
Bacterial meningitis is defined as serious inflammation of the central nervous system (CNS)
in which bacteria infect the blood–brain barrier (BBB), a network of highly specialized brain …

Synthesis and Characterization of quercetin–iron complex nanoparticles for overcoming drug resistance

L Prestianni, ER Espinal, SF Hathcock, N Vollmuth… - Pharmaceutics, 2023 - mdpi.com
Quercetin, one of the major natural flavonoids, has demonstrated great pharmacological
potential as an antioxidant and in overcoming drug resistance. However, its low aqueous …

Transcriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells

SF Hathcock, J Mamana, TE Keyzer… - Journal of …, 2024 - journals.asm.org
Viral aseptic meningitis is a neuroinflammatory condition that occurs when viruses gain
access to the central nervous system (CNS) and induce inflammation. The blood–brain …

Induced Pluripotent Stem Cell (iPSC)-Derived Endothelial Cells to Study Bacterial–Brain Endothelial Cell Interactions

ER Espinal, SJ Sharp, BJ Kim - The Blood-Brain Barrier: Methods and …, 2022 - Springer
Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs
when blood-borne bacteria are able to exit the cerebral vasculature and cause inflammation …

Group B Streptococcus transcriptome when interacting with brain endothelial cells

N Vollmuth, BE Bridgers, ML Armstrong… - Journal of …, 2024 - Am Soc Microbiol
Bacterial meningitis is a life-threatening infection of the central nervous system (CNS) that
occurs when bacteria are able to cross the blood–brain barrier (BBB) or the meningeal …

Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

LM Endres, M Jungblut, M Divyapicigil, M Sauer… - Fluids and Barriers of …, 2022 - Springer
Background Bacterial meningitis is a life-threatening disease that occurs when pathogens
such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier …

The Role of Sphingosine 1-phosphate and S1PR1-3 in the Pathophysiology of Meningococcal Meningitis

I Fohmann - 2024 - search.proquest.com
Neisseria meningitidis (N. meningitidis) is an obligate human pathogen which causes live-
threatening sepsis and meningitis. The fatality rate after meningococcal infection is high and …

Natural Animal Models to Study Neisserial Asymptomatic Colonization and Persistence

E Thapa - 2022 - rave.ohiolink.edu
Members of the genus Neisseria are common mucosal commensals of animals and
humans. Two species, Neisseria meningitidis and Neisseria gonorrhoeae cause diseases …