Drugs for the treatment of Zika virus infection

JA Bernatchez, LT Tran, J Li, Y Luan… - Journal of medicinal …, 2019 - ACS Publications
Zika virus is an emerging flavivirus that causes the neurodevelopmental congenital Zika
syndrome and that has been linked to the neuroinflammatory Guillain–Barré syndrome. The …

[HTML][HTML] Envelope Protein-Targeting Zika Virus Entry Inhibitors

A Roy, Q Liu, Y Yang, AK Debnath, L Du - International Journal of …, 2024 - mdpi.com
Zika virus (ZIKV; family, Flaviviridae), which causes congenital Zika syndrome, Guillain-
Barré Syndrome, and other severe diseases, is transmitted mainly by mosquitoes; however …

Flexible synthetic carbohydrate receptors as inhibitors of viral attachment

MF Bravo, MA Lema, M Marianski… - Biochemistry, 2020 - ACS Publications
Carbohydrate–receptor interactions are often involved in the docking of viruses to host cells,
and this docking is a necessary step in the virus life cycle that precedes infection and …

Molecular engineering of carbohydrate recognition

Z Sun, B Fan, MJ Webber - ChemSystemsChem, 2023 - Wiley Online Library
Carbohydrates play a number of structural, functional, and metabolic roles in underpinning
natural life processes, acting in states of both health and disease. Given this importance …

A synthetic galectin mimic

BJJ Timmer, A Kooijman, X Schaapkens… - Angewandte Chemie …, 2021 - Wiley Online Library
Galectins are a galactoside specific subclass of carbohydrate binding proteins (lectins)
involved in various cellular activities, certain cancers, infections, inflammations, and many …

Towards Biomimetic Recognition of Glycans by Synthetic Receptors

F Milanesi, S Roelens, O Francesconi - ChemPlusChem, 2024 - Wiley Online Library
Carbohydrates are abundant in Nature, where they are mostly assembled within glycans as
free polysaccharides or conjugated to a variety of biological molecules such as proteins and …

Synthesis and antiviral activity of diverse heterocyclic scaffolds

S Sharma, D Utreja - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Heterocyclic moieties form a major part of organic chemistry as they are widely distributed in
nature and have wide scale practical applications ranging from extensive clinical use to …

Medicinal chemistry strategies toward broad-spectrum antiviral agents to prevent next pandemics

Z Lü, X Dai, J Xu, Z Liu, Y Guo, Z Gao… - European Journal of …, 2024 - Elsevier
The pandemic and tremendous impact of severe acute respiratory syndrome coronavirus 2
alert us, despite great achievements in prevention and control of infectious diseases, we still …

Synthesis and Binding of Mannose‐Specific Synthetic Carbohydrate Receptors

MF Bravo, K Palanichamy, MA Shlain… - … A European Journal, 2020 - Wiley Online Library
Synthetic carbohydrate receptors (SCRs) that selectively recognize cell‐surface glycans
could be used for detection, drug delivery, or as therapeutics. Here we report the synthesis …

Molecular basis of N-glycan recognition by pradimicin a and its potential as a SARS-CoV-2 entry inhibitor

Y Nakagawa, M Fujii, N Ito, M Ojika, D Akase… - Bioorganic & Medicinal …, 2024 - Elsevier
Virus entry inhibitors are emerging as an attractive class of therapeutics for the suppression
of viral transmission. Naturally occurring pradimicin A (PRM-A) has received particular …