Advances in anti-tumor treatments targeting the CD47/SIRPα axis
W Zhang, Q Huang, W Xiao, Y Zhao, J Pi, H Xu… - Frontiers in …, 2020 - frontiersin.org
CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer
cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the …
cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the …
The landscape overview of CD47-based immunotherapy for hematological malignancies
H Yang, Y Xun, H You - Biomarker Research, 2023 - Springer
Extensive clinical and experimental evidence suggests that macrophages play a crucial role
in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy …
in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy …
Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo
Tumor-associated macrophages (TAMs) represent an important cellular subset within the
glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs …
glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs …
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
Idiopathic inflammatory myopathies cause progressive muscle weakness and degeneration.
Since high-dose glucocorticoids might not lead to full recovery of muscle function, physical …
Since high-dose glucocorticoids might not lead to full recovery of muscle function, physical …
Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity
CD47 is a ubiquitously expressed cell surface receptor, which is widely known for
preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein …
preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein …
[HTML][HTML] Deciphering the role of CD47 in cancer immunotherapy
L Weng, Y Wang, J Zhang, Q Wu, P Zhao, Y Shi… - Journal of Advanced …, 2024 - Elsevier
Background Immunotherapy has emerged as a novel strategy for cancer treatment following
surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric …
surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric …
Coordinated dialogue between UHRF1 and DNMT1 to ensure faithful inheritance of methylated DNA patterns
DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
The role of IL-7 in immunity and cancer
Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly
regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for …
regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for …
Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …
Glioblastoma immunotherapy targeting the innate immune checkpoint CD47-SIRPα axis
J Hu, Q Xiao, M Dong, D Guo, X Wu… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma Multiforme (GBM) is the most common and aggressive form of intracranial
tumors with poor prognosis. In recent years, tumor immunotherapy has been an attractive …
tumors with poor prognosis. In recent years, tumor immunotherapy has been an attractive …