Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats

MM Aglawe, MB Kale, SR Rahangdale… - Brain research …, 2021 - Elsevier
Chronic maternal ethanol exposure leads to poor intelligence, impaired cognition and array
of neurological symptoms in offsprings and commonly referred as fetal alcohol spectrum …

Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats

M Kale, N Nimje, MM Aglawe, M Umekar, B Taksande… - Brain research, 2020 - Elsevier
Epidemiological studies indicated that mood disorders like depression and anxiety are
highly prevalent in type-II diabetes mellitus (T2DM). However, the neurobiological …

Pharmacological profile of agmatine: An in-depth overview

H Rafi, H Rafiq, M Farhan - Neuropeptides, 2024 - Elsevier
Agmatine, a naturally occurring polyamine derived from arginine via arginine
decarboxylase, has been shown to play multifaceted roles in the mammalian body …

Possible involvement of GABAergic system on central amygdala Mediated anxiolytic effect of agmatine in rats

NP Paliwal, BG Taksande, SP Jain… - International Journal of …, 2024 - Taylor & Francis
Objectives To study the pharmacological interactions between agmatine and gamma
aminobutyric acid (GABA) modulatory agents in the regulation of anxiety-like behavior in …

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder

MB Kale, SR Rahangdale, TA Banarase… - Neuroscience …, 2025 - Elsevier
Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by
associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable …

Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

R Katariya, K Mishra, S Sammeta, M Umekar… - NeuroToxicology, 2024 - Elsevier
Huntington's disease (HD) is a progressive neurodegenerative condition characterized by a
severe motor incoordination, cognitive decline, and psychiatric complications. However, a …

Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice

N Kotagale, S Rahmatkar, S Chauragade, M Dixit… - Neurotoxicology, 2020 - Elsevier
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder
characterized by abnormal accumulation of extracellular β-amyloid (Aβ) plaques and …

The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress

S Yan, C Xu, M Yang, H Zhang, Y Cheng, Z Xue… - …, 2023 - Elsevier
Agmatine is an endogenous polyamine produced from l-arginine and degraded by
agmatinase (AGMAT). Studies in humans and animals have shown that agmatine has …

Agmatine reverses memory deficits induced by Aβ1–42 peptide in mice: A key role of imidazoline receptors

N Kotagale, M Dixit, H Garmelwar, S Bhondekar… - Pharmacology …, 2020 - Elsevier
Abstracts Agmatine is a biogenic amine synthesized following decarboxylation of L-arginine
by the enzyme arginine decarboxylase and exhibits favourable outcome in …

Inhibitory influence of agmatine in ethanol withdrawal-induced depression in rats: behavioral and neurochemical evidence

N Chimthanawala, S Patil, R Agrawal, NR Kotagale… - Alcohol, 2020 - Elsevier
Although ethanol withdrawal depression is one of the prominent reasons for ethanol
consumption reinstatement and ethanol dependence, its neurochemical basis is not clearly …