Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis

J Kuang, J Wang, Y Li, M Li, M Zhao, K Ge, D Zheng… - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

A researcher's guide to preclinical mouse NASH models

S Gallage, JEB Avila, P Ramadori, E Focaccia… - Nature …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …

Understanding the role of the gut microbiome and microbial metabolites in non-alcoholic fatty liver disease: current evidence and perspectives

N Vallianou, GS Christodoulatos, I Karampela… - Biomolecules, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

J Aron-Wisnewsky, C Vigliotti, J Witjes, P Le… - Nature Reviews …, 2020 - nature.com
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations

Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …

From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …