This review describes the diffusion model for light transport in tissues and the medical
applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue …

The authors describe the development of diffuse optical imaging (DOI) technologies,
specifically the use of spatial and temporal modulation to control near infrared light …

We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-
dimensional in vivo imaging of human breast tumor based on large optical data sets. Images …

The prospective multicenter ACRIN 6691 trial was designed to evaluate whether changes
from baseline to mid-therapy in a diffuse optical spectroscopic imaging (DOSI)–derived …

Diffuse optical imaging is a medical imaging technique that is beginning to move from the
laboratory to the hospital. It is a natural extension of near-infrared spectroscopy (NIRS) …

Approximately 8–20% of breast cancer patients receiving neoadjuvant chemotherapy fail to
achieve a measurable response and endure toxic side effects without benefit. Most clinical …

Tissue hemoglobin oxygen saturation (ie, oxygenation) is a functional imaging endpoint that
can reveal variations in tissue hypoxia, which may be predictive of pathologic response in …

Diffuse optical spectroscopic imaging (DOSI) non-invasively and quantitatively measures
tissue haemoglobin, water and lipid. Pilot studies in small groups of patients demonstrate …

Purpose To assess initial breast tumor hemoglobin (Hb) content before the initiation of
neoadjuvant chemotherapy, monitor the Hb changes at the end of each treatment cycle, and …

Purpose To investigate the potential role of optical tomography in the near-infrared (NIR)
spectrum with ultrasonographic (US) localization as a means of differentiating early-stage …