Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …

The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and
revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting …

Biomedical single-cell atlases describe disease at the cellular level. However, analysis of
this data commonly focuses on cell-type-centric pairwise cross-condition comparisons …

Multiple sclerosis is a chronic neuroinflammatory disorder characterized by demyelination,
oligodendrocyte damage/loss and neuroaxonal injury in the context of immune cell …

Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the
CNS. The disease course in MS is highly variable and driven by a combination of relapse …

Myelin, the membrane surrounding neuronal axons, is critical for central nervous system
(CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological …

Immune-mediated inflammatory diseases (IMIDs) are responsible for substantial global
disease burden and associated health-care costs. Traditional models of research and …

Multiple sclerosis (MS) is an autoimmune disease of the CNS, featuring inflammation and
demyelination with variable recovery. In this issue of the JCI, Kapell, Fazio, and authors …