Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Staphylococcus aureus is frequently isolated from the skin of atopic dermatitis (AD) patients
during flares. The normal microbiota is disrupted and the diversity of the microorganisms on …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Skin barrier structure and function is essential to human health. Hitherto unrecognized
functions of epidermal keratinocytes show that the skin plays an important role in adapting …

Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections, which
cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus …

Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various
disorders such as xerosis cutis, ichthyoses, and atopic dermatitis. Filaggrin is a pivotal …

Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that
includes imbalanced immune system signalling, impaired skin barrier and enhanced …

Staphylococcus aureus commonly colonizes the skin of atopic dermatitis (AD) patients and
contributes to the development and exacerbation of AD. Multiple factors are associated with …

Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S.
aureus) in lesional and non-lesional skin. A skin infection may become systemic if left …

Patients with atopic dermatitis (AD) are commonly colonized with Staphylococcus aureus
(AD S. aureus+), but what differentiates this group from noncolonized AD patients (AD S …