Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments
D Debanne, K Mylonaki, ML Musella… - Trends in Pharmacological …, 2024 - cell.com
Epileptic encephalopathies are generally considered to be functional disruptions in the
balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion …
balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion …
Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders
IE Faulkner, RZ Pajak, MK Harte, JD Glazier… - Frontiers in cellular …, 2024 - frontiersin.org
Voltage-gated potassium channels are a widely distributed subgroup of potassium channels
responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence …
responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence …
The binding and mechanism of a positive allosteric modulator of Kv3 channels
Q Liang, G Chi, L Cirqueira, L Zhi, A Marasco… - Nature …, 2024 - nature.com
Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide
range of neurological disorders. However, developing effective modulators requires …
range of neurological disorders. However, developing effective modulators requires …
Opening the KV3. 1 gates: A therapeutic strategy for progressive myoclonus epilepsy type 7?
MA Gandini, GW Zamponi - Cell Reports Medicine, 2024 - cell.com
Opening the KV3.1 gates: A therapeutic strategy for progressive myoclonus epilepsy type 7?:
Cell Reports Medicine Skip to Main Content Advertisement Cell Reports Medicine All content is …
Cell Reports Medicine Skip to Main Content Advertisement Cell Reports Medicine All content is …
[HTML][HTML] Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy
ER Wengert, MA Cheng, SR Liebergall… - …, 2024 - pmc.ncbi.nlm.nih.gov
The recurrent pathogenic variant KCNC1-p. Ala421Val (A421V) is a cause of developmental
and epileptic encephalopathy characterized by moderate-to-severe developmental …
and epileptic encephalopathy characterized by moderate-to-severe developmental …