Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Objectives Mechanical force plays an important role in modulating stem cell fate and
behaviours. However, how periodontal ligament stem cells (PDLSCs) perceive mechanical …

Objective Cartilage health is maintained in response to a range of mechanical stimuli
including compressive, shear and tensile strains and associated alterations in osmolality …

There is a complex interaction between titanium dental implants, bone, and the immune
system. Among them, specific immune cells, macrophages play a crucial role in the …