From Nucleosomes to Compartments: Physicochemical Interactions Underlying Chromatin Organization
Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …
genetic information. However, understanding chromatin folding is challenging due to its …
Post-translational modification of lamins: mechanisms and functions
M Zheng, G Jin, Z Zhou - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Lamins are the ancient type V intermediate filament proteins contributing to diverse
biological functions, such as the maintenance of nuclear morphology, stabilization of …
biological functions, such as the maintenance of nuclear morphology, stabilization of …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Current understanding of molecular phase separation in chromosomes
JK Ryu, DE Hwang, JM Choi - International Journal of Molecular Sciences, 2021 - mdpi.com
Biomolecular phase separation denotes the demixing of a specific set of intracellular
components without membrane encapsulation. Recent studies have found that biomolecular …
components without membrane encapsulation. Recent studies have found that biomolecular …
Exploring chromosomal structural heterogeneity across multiple cell lines
Using computer simulations, we generate cell-specific 3D chromosomal structures and
compare them to recently published chromatin structures obtained through microscopy. We …
compare them to recently published chromatin structures obtained through microscopy. We …
The interplay of chromatin phase separation and lamina interactions in nuclear organization
The genetic material of eukaryotes is segregated into transcriptionally active euchromatin
and silent heterochromatin compartments. The spatial arrangement of chromatin …
and silent heterochromatin compartments. The spatial arrangement of chromatin …
Explicit ion modeling predicts physicochemical interactions for chromatin organization
Molecular mechanisms that dictate chromatin organization in vivo are under active
investigation, and the extent to which intrinsic interactions contribute to this process remains …
investigation, and the extent to which intrinsic interactions contribute to this process remains …
Compartmentalization with nuclear landmarks yields random, yet precise, genome organization
The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …
While significant progress has been made in deciphering the folding mechanisms of …
A liquid state perspective on dynamics of chromatin compartments
The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
Symmetry-based classification of forces driving chromatin dynamics
Chromatin–the functional form of DNA in the cell–exists in the form of a polymer immersed in
a nucleoplasmic fluid inside the cell nucleus. Both chromatin and nucleoplasm are subject to …
a nucleoplasmic fluid inside the cell nucleus. Both chromatin and nucleoplasm are subject to …