Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease with systemic involvement
that affects about 1% of the Western population. The progressive destruction of affected …

Rheumatoid arthritis (RA) is common human autoimmune disease with chronic joint
inflammation and bone destruction. Macrophages, T lymphocytes and osteoclasts are …

This study was undertaken to investigate the immunomodulatory effect of clarithromycin
against synovial fibroblast‐like cells (synoviocytes). Synovial tissue obtained from …

The mechanism of fibroblast-like synoviocyte (FLS) transformation into an inflammatory
phenotype in rheumatoid arthritis (RA) is not fully understood. FLS interactions with invading …

We investigated the cellular and humoral interactions between peripheral blood
mononuclear cells (PBMCs) and human osteoblasts, leading to apoptosis of osteoblasts …

The present study was undertaken to investigate the immunoregulatory effects of T-614 (3-
formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one) on synovial cells …

Objective. To study the presence of estrogen‐binding sites (EBS) in the synovial tissues of
male and female patients with rheumatoid arthritis (RA) and in age and sex‐matched …

Objective. To investigate the mitogenic and anti‐apoptotic effects of transforming growth
factor β1 (TGFβ) on rheumatoid synovial cells in vitro. Methods. Synovial cells were cultured …

This paper describes the immunoregulatory effects of interleukin‐10 (IL‐10) on synovial
cells in vitro. Synovial cells were cultured with IL‐10 in the presence or absence of various …

Although acute inflammation is a healthy physiological response indicative of wound
healing, chronic inflammation has been directly implicated in a wide range of degenerative …