Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …

Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement
therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward …

Abstract N6-methyladenosine (m6A) is the most abundant chemical modification in mRNA
and plays important roles in human and mouse embryonic stem cell pluripotency …

Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for
disease modeling and the treatment of diabetes. SC-islets can be genetically modified …

Summary Type 1 (T1D) or type 2 diabetes (T2D) are caused by a deficit of functional insulin-
producing β cells. Thus, the identification of β cell trophic agents could allow the …

Background & aims The CEL gene encodes the digestive enzyme carboxyl ester lipase.
CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant …