Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …

Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

Multiple sclerosis (MS) is a chronic progressive disabling disease of the central nervous
system (CNS) characterized by demyelination and neuronal injury. Dyslipidemia is observed …

Motivated by the clinical observation that interruption of the mevalonate pathway stimulates
immune responses, we hypothesized that this pathway may function as a druggable target …

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

The pathobiology of atherosclerosis and its current and potential future treatments are
summarized, with a spotlight on three central cell types involved:(i) endothelial cells …

Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic
compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in …

Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been
followed with great concern during the last years, while the need for new drugs able to …

Background Multiple sclerosis (MS) is a chronic inflammatory disease that leads to
progressive disability. Statins [hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors] …