The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

INTRODUCTION The epidemic of substance use disorders and drug overdose deaths is a
growing public health crisis in the United States. Every day, 174 people die from drug …

Clinical treatment of Osteosarcoma (OS) encounters great challenges of postsurgical tumor
recurrence and extensive bone defect. To address these issues, innovative multifunctional …

Bone defects are a common disease threatening the health of many people. Calcium
phosphate (CaP) is an ideal bone substitutive material that is widely used for bone repair …

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …

Repair and reconstruction of critical-sized bone defects has always been a difficult task in
orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role in bone defect …

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects
that include certain types of cancers and strokes, hence the ongoing quest for the discovery …

Mechanically induced biological responses in bone cells involve a complex biophysical
process. Although various mechanosensors have been identified, the precise …

Osteosarcoma (OS) is an adolescent and young adult malignancy that mostly occurs in long
bones. The treatment of OS is still a big challenge for clinicians due to increasing …