Synthesis methods of 1, 2, 3-/1, 2, 4-triazoles: A review

J Dai, S Tian, X Yang, Z Liu - Frontiers in Chemistry, 2022 - frontiersin.org
Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers
1, 2, 3-triazole and 1, 2, 4-triazole. Compounds containing a triazole are one of the …

Recent developments on 1, 2, 4-triazole nucleus in anticancer compounds: a review

R Kaur, A Ranjan Dwivedi, B Kumar… - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …

Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships

M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …

Design and synthesis of novel quinoline/chalcone/1, 2, 4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases

AM Mohassab, HA Hassan, D Abdelhamid… - Bioorganic …, 2021 - Elsevier
New quinoline/chalcone hybrids containing 1, 2, 4-triazole moiety have been designed,
synthesized and their structures elucidated and confirmed by various spectroscopic …

Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi …

J Haribabu, V Garisetti, RE Malekshah… - Journal of molecular …, 2022 - Elsevier
Abstract Two heterocyclic azole compounds, 3-(2, 3-dihydrobenzo [d] thiazol-2-yl)-4H-
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …

The effect of 1, 2, 4-triazole-3-thiol derivatives bearing hydrazone moiety on cancer cell migration and growth of melanoma, breast, and pancreatic cancer spheroids

A Šermukšnytė, K Kantminienė, I Jonuškienė… - Pharmaceuticals, 2022 - mdpi.com
4-Phenyl-3-[2-(phenylamino) ethyl]-1 H-1, 2, 4-triazole-5 (4 H)-thione was used as a starting
compound for the synthesis of the corresponding 1, 2, 4-triazol-3-ylthioacetohydrazide …

1, 2, 4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents

J Zhang, S Wang, Y Ba, Z Xu - European journal of medicinal chemistry, 2019 - Elsevier
Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

Recent developments on triazole nucleus in anticonvulsant compounds: a review

MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …

Recent advances in 1, 2, 4‐triazole scaffolds as antiviral agents

SA El‐Sebaey - ChemistrySelect, 2020 - Wiley Online Library
In recent years, severe viral infections have emerged, and antiviral chemotherapeutic agents
are not adequately effective in curing these infections, leading to serious human diseases …

Chemistry and biological activities of 1, 2, 4-triazolethiones—antiviral and anti-infective drugs

AA Aly, A A. Hassan, MM Makhlouf, S Bräse - Molecules, 2020 - mdpi.com
Mercapto-substituted 1, 2, 4-triazoles are very interesting compounds as they play an
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …