The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Multidimensional analyses have demonstrated the presence of a unique tumor
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …

Macrophages act as scavengers, modulating the immune response against pathogens and
maintaining tissue homeostasis. Metabolism governs macrophage differentiation …