Extracellular vesicles (EVs, including exosomes) are implicated in many aspects of nervous
system development and function, including regulation of synaptic communication, synaptic …

Peripheral nerve injury is a major clinical problem and often results in a poor functional
recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal …

After peripheral nerve injury, axons regenerate and become remyelinated by resident
Schwann cells. However, myelin repair never results in the original myelin thickness …

Introduction: Application of regenerative medicine strategies for repair of organs/tissue
impacted by chronic disease is an active subject for product development. Such …

Injuries to peripheral nerves can cause paralysis and sensory disturbances, but such
functional impairments are often short lived because of efficient regeneration of damaged …

The loss of neurons and degeneration of axons after spinal cord injury result in the loss of
sensory and motor functions. A bridging biomaterial construct that allows the axons to grow …

Background The development of new treatment strategies to improve peripheral nerve
repair after injury, especially those that accelerate axonal nerve regeneration, is very …

Nerve injury and nerve pain are common diseases caused by neuroinflammation.
Numerous studies have shown that the activation of NLRP3 (nod-like receptor family, pyrin …

Injury of a peripheral nerve (PNI) leads to both ischemic and inflammatory alterations. Sciatic
nerve injury (SNI) represents the most widely used model for PNI. Mesenchymal stem cell …

The eye is innervated by neurons derived from both the central nervous system and
peripheral nervous system (PNS). While much is known about retinal neurobiology and …