The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

Fluorinated analogues of the canonical α-L-amino acids have gained widespread attention
as building blocks that may endow peptides and proteins with advantageous biophysical …

The CH/π hydrogen bond is an attractive molecular force occurring between a soft acid and
a soft base. Contribution from the dispersion energy is important in typical cases where …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Organic chemists tend to consider the conformation of compounds as a consequence of
repulsive steric interactions. In other words,“the steric effect” means “repulsive” in many …

Proline residues have unique roles in protein folding, structure, and function. Proline and the
aromatic amino acids comprise the encoded cyclic protein residues. Aromatic protein side …

This treatise is an update to a preceding highlight (CH/π hydrogen bonds in crystals)
published in this journal 5 years ago (M. Nishio, CrystEngComm, 2004, 6, 130–156). After …

Abstract Background The Ramachandran plot is a fundamental tool in the analysis of protein
structures. Of the 4 basic types of Ramachandran plots, the interactions that determine the …

Proteins may vary from being rigid to having flexible regions to being completely disordered,
either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered …

Hydrogen bonds, X–H⋯ A, formed by weak donors (X= C) and acceptors (A= π system) were
generally dismissed as being of little consequence before and even during the 1970s. This …