Introduction The development of an effective vaccine to protect against HIV is a longstanding
global health need complicated by challenges inherent to HIV biology and to the execution …

Studies on HIV virology and pathogenesis address the complex mechanisms that result in
the HIV infection of the cell and destruction of the immune system. These studies are …

There is intense interest in developing curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …

Macrophages are important target cells for the Human Immunodeficiency Virus Type I (HIV-
1) in vivo. Several studies have assessed the molecular biology of the virus in this cell type …

Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the
monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T …

Viral infections are a major cause of human disease. Although most viruses replicate in
peripheral tissues, some have developed unique strategies to move into the nervous …

Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …

Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for
which successful therapeutic options are still being investigated. Challenges facing current …

Macrolides are a diverse class of hydrophobic compounds characterized by a macrocyclic
lactone ring and distinguished by variable side chains/groups. Some of the most well …

Even with optimal antiretroviral therapy, human immunodeficiency virus (HIV) persists in
plasma, blood cells, and tissues. To develop new therapies, it is essential to know what cell …