[HTML][HTML] Brain default-mode network dysfunction in addiction

R Zhang, ND Volkow - Neuroimage, 2019 - Elsevier
Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine

MS Lener, MJ Niciu, ED Ballard, M Park, LT Park… - Biological …, 2017 - Elsevier
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …

Circuit mechanisms of reward, anhedonia, and depression

A Höflich, P Michenthaler, S Kasper… - International Journal …, 2019 - academic.oup.com
Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects

AC Nugent, ED Ballard, TD Gould, LT Park… - Molecular …, 2019 - nature.com
Ketamine's mechanism of action was assessed using gamma power from
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …

Searching for cross-diagnostic convergence: neural mechanisms governing excitation and inhibition balance in schizophrenia and autism spectrum disorders

JH Foss-Feig, BD Adkinson, JL Ji, G Yang, VH Srihari… - Biological …, 2017 - Elsevier
Recent theoretical accounts have proposed excitation and inhibition (E/I) imbalance as a
possible mechanistic, network-level hypothesis underlying neural and behavioral …

Associations of regional GABA and glutamate with intrinsic and extrinsic neural activity in humans—a review of multimodal imaging studies

NW Duncan, C Wiebking, G Northoff - Neuroscience & Biobehavioral …, 2014 - Elsevier
The integration of multiple imaging modalities is becoming an increasingly well used
research strategy for studying the human brain. The neurotransmitters glutamate and GABA …

[HTML][HTML] Functional connectivity is associated with altered brain chemistry in women with endometriosis-associated chronic pelvic pain

S As-Sanie, J Kim, T Schmidt-Wilcke, PC Sundgren… - The Journal of …, 2016 - Elsevier
In contrast to women with relatively asymptomatic endometriosis, women with endometriosis-
associated chronic pelvic pain (CPP) exhibit nonpelvic hyperalgesia and decreased gray …

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

LA Ajram, J Horder, MA Mendez… - Translational …, 2017 - nature.com
Currently, there are no effective pharmacologic treatments for the core symptoms of autism
spectrum disorder (ASD). There is, nevertheless, potential for progress. For example, recent …

Glutamate-mediated excitotoxicity in schizophrenia: a review

E Plitman, S Nakajima, C de la Fuente-Sandoval… - European …, 2014 - Elsevier
Findings from neuroimaging studies in patients with schizophrenia suggest widespread
structural changes although the mechanisms through which these changes occur are …

Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction

WJ Gao, SS Yang, NR Mack, LA Chamberlin - Molecular psychiatry, 2022 - nature.com
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …