Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Targeting neuroinflammation in Alzheimer's disease: From mechanisms to clinical applications

ZZ Si, CJ Zou, X Mei, XF Li, H Luo, Y Shen… - Neural regeneration …, 2023 - journals.lww.com
Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether neurofilament light (NfL), glial fibrillary acidic protein
(GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to …

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

AM Arranz, B De Strooper - The Lancet Neurology, 2019 - thelancet.com
Background Astrocytes, also called astroglia, maintain homoeostasis of the brain by
providing trophic and metabolic support to neurons. They recycle neurotransmitters …

Neurofilament light as a biomarker in traumatic brain injury

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL,
traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor …

Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

P Preman, M Alfonso-Triguero, E Alberdi… - Cells, 2021 - mdpi.com
Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

Mapping astrogliosis in the individual human brain using multidimensional MRI

D Benjamini, DS Priemer, DP Perl, DL Brody… - Brain, 2023 - academic.oup.com
There are currently no non-invasive imaging methods available for astrogliosis assessment
or mapping in the central nervous system despite its essential role in the response to many …

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

HC Murray, C Osterman, P Bell, L Vinnell… - Acta Neuropathologica …, 2022 - Springer
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repetitive head trauma and is characterised by the perivascular accumulation of …

Is Alzheimer's disease an inflammasomopathy?

CF Pereira, AE Santos, PI Moreira, AC Pereira… - Ageing research …, 2019 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite
the tremendous efforts researchers have put into AD research, there are no effective options …

[HTML][HTML] The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer's disease model

M Wirianto, CY Wang, E Kim, N Koike… - The FASEB …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there is a
pressing need to identify disease‐modifying factors and devise interventional strategies. The …