Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Background Alzheimer's disease (AD) is an insidious, irreversible, and progressive
neurodegenerative health condition manifesting as cognitive deficits and amyloid beta (Aβ) …

The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …

Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in
Wnt signalling and are essential for developing and adult organisms,. As central mediators …

Genetic, biochemical, and anatomical grounds led to the proposal of the amyloid cascade
hypothesis centered on the accumulation of amyloid beta peptides (Aβ) to explain …

Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder
characterized by cognitive deficiency and development of amyloid-β (Aβ) plaques and …

Alzheimer's disease (AD) is a neurodegenerative brain disorder that has an increasingly
large burden on health and social care systems. The pathophysiology involves the …

The intramembrane protease γ-secretase activates important signaling molecules, such as
Notch receptors. It is still unclear, however, how different elements within the primary …