The mammalian liver consists of hexagon-shaped lobules that are radially polarized by
blood flow and morphogens,,,. Key liver genes have been shown to be differentially …

The toxic properties of various nitrosamines in animals and humans are well established.
The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) …

The objective of omics studies is to globally measure the different classes of cellular
biomolecules present in a biological specimen (eg proteins, metabolites) as accurately as …

The RAS pathway is a highly conserved cascade of protein-protein interactions and
phosphorylation that is at the heart of signalling networks that govern proliferation …

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third
leading cause of cancer related mortality with a 10 year survival rate of merely 22–35 …

There is an ongoing interest in cellular antioxidants and oxidants as well as cellular
mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic …

Costello syndrome is a" RASopathy" that is characterized by growth retardation, dysmorphic
facial appearance, hypertrophic cardiomyopathy and tumor predisposition.> 80% of patients …

The liver is the primary organ to sequester nanodrugs, representing a substantial hurdle for
drug delivery and raising toxicity concerns. However, the mechanistic details underlying the …

CTNNB1, encoding the ß-catenin protein, is a key oncogene contributing to liver
carcinogenesis. Hepatocellular carcinoma (HCC) is the most common form of primary liver …