Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Pathogenomics of uterine fibroids development

VS Baranov, NS Osinovskaya… - International journal of …, 2019 - mdpi.com
We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

The mechanism and function of epigenetics in uterine leiomyoma development

Q Yang, A Mas, MP Diamond… - Reproductive …, 2016 - journals.sagepub.com
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

[HTML][HTML] TET protein inhibitors: Potential and limitations

R Kaplánek, Z Kejík, J Hajduch, K Veselá… - Biomedicine & …, 2023 - Elsevier
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …

Update on the role and regulatory mechanism of extracellular matrix in the pathogenesis of uterine fibroids

Q Yang, A Al-Hendy - International Journal of Molecular Sciences, 2023 - mdpi.com
Uterine fibroids (UFs), also known as leiomyomas, are benign tumors of the myometrium
affecting over 70% of women worldwide, particularly women of color. Although benign, UFs …

5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer

LI Kroeze, BA van der Reijden, JH Jansen - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …

H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas

T Cao, Y Jiang, Z Wang, N Zhang, A Al-Hendy… - Oncogene, 2019 - nature.com
Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic
smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting~ 80 …

Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

M Włodarczyk, M Ciebiera, G Nowicka, T Łoziński… - Nutrients, 2024 - mdpi.com
The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal,
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …

A view on uterine leiomyoma genesis through the prism of genetic, epigenetic and cellular heterogeneity

AS Koltsova, OA Efimova, AA Pendina - International Journal of …, 2023 - mdpi.com
Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are
associated with a range of symptoms and significant morbidity. Despite extensive research …